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Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 480-489 doi: 10.1007/s11684-017-0594-8

Abstract:

Superinfection is frequently detected among individuals infected by human immunodeficiency virus typeI (HIV-1).This observation indicates that the immune responses elicited by natural HIV-1 infection may play a roleThus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses thanand if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1

Keywords： human immunodeficiency virus type I     superinfection     incidence     immune response    

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Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 933-937 doi: 10.1007/s11684-021-0860-7

Abstract: Neurofibromatosis (NF) is a genetic disease in which the lungs are rarely involved. However, in NF cases with lung involvement, chest computed tomography may show bilateral basal reticulations, apical bullae, and cysts without bronchiectasis. Herein, we report a patient diagnosed with NF on the basis of the results of genetic testing who presented with early-onset wet cough and bronchiectasis. Considering the differential diagnosis of bronchiectasis combined with his early-onset wet cough, sinusitis, and sperm quality decline, we considered the possibility of primary ciliary dyskinesia (PCD). Further electron microscopy analysis of cilia and identification of homozygous mutations in the RSPH4A gene confirmed the diagnosis of PCD. Therefore, for patients with NF, when an image change exists in the lungs that does not correspond to NF, the possibility of other diagnoses, including PCD, must be considered.

Keywords： primary ciliary dyskinesia     neurofibromatosis     bronchiectasis     transmission electron microscopy     genetic sequencing    

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Properties of La1-xCexCoO3 system perovskite-type catalysts for diesel engine exhaust removal

GONG Cairong, FAN Guoliang, HOU Yanfeng, ZHANG Zhongrong, SONG Chonglin, HUANG Qifei

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 1,   Pages 6-10 doi: 10.1007/s11705-007-0002-z

Abstract: A series of complex oxide LaCeCoO catalysts was synthesized at a low temperature through a combustion process, in which x is among 0, 0.1, 0.2, 0.4 and 0.6 corresponding to the quantity of La partial substitution by Ce. The catalysts were characterized for phase composition using chemical analysis and X-ray diffraction. The catalytic activity of the catalysts in removal of NO, total hydrocarbon (THC) and particulate matter (PM) from diesel exhaust gases were examined in detail using temperature-programmed reaction technique. The results show that after partial substitution of La with Ce, the oxygen vacancy concentration increases significantly and a Co-Co system is formed. Consequently, the catalytic activity in the removal of THC and NO is significantly improved. But for the PM, the effect is not so obvious. The possible catalytic mechanism for this was presented. It is also worth noting that the doped catalysts showed good stability.

Keywords： catalytic mechanism     combustion     corresponding     LaCeCoO     catalytic activity    

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Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 36-40 doi: 10.1007/s11684-009-0020-y

Abstract: of β-elemene on the secretion of angiotensin II (ANG II) and the expression of angiotensin receptor type1 (AT1R) in hepatic stellate cells (HSCs)The protein expression of AT1R was detected by western blot.( <0.05), but 10 mg/L β-elemene had no such effect. β-elemene significantly reduced the amount of AT1RThe expression of AT1R protein also decreased after the treatment with β-elemene for 24 h. β-elemene

Keywords： liver cirrhosis     beta-elemene     hepatic stellate cells     angiotensin II     receptor     angiotensin     type 1    

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New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 17-24 doi: 10.1007/s11684-021-0873-2

Abstract: Obesity is an important risk factor of type 2 diabetes (T2D), which has become an important factor threateningSemaglutide is a kind of human glucagon-like peptide-1 (GLP-1) analog that promotes insulin secretionGLP-1 can also delay stomach emptying and suppress appetite to help lose weight.

Keywords： semaglutide     type 2 diabetes     obesity    

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Molecular network-based intervention brings us closer to ending the HIV pandemic

Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 136-148 doi: 10.1007/s11684-020-0756-y

Abstract: Precise identification of HIV transmission among populations is a key step in public health responses. However, the HIV transmission network is usually difficult to determine. HIV molecular networks can be determined by phylogenetic approach, genetic distance-based approach, and a combination of both approaches. These approaches are increasingly used to identify transmission networks among populations, reconstruct the history of HIV spread, monitor the dynamics of HIV transmission, guide targeted intervention on key subpopulations, and assess the effects of interventions. Simulation and retrospective studies have demonstrated that these molecular network-based interventions are more cost-effective than random or traditional interventions. However, we still need to address several challenges to improve the practice of molecular network-guided targeting interventions to finally end the HIV epidemic. The data remain limited or difficult to obtain, and more automatic real-time tools are required. In addition, molecular and social networks must be combined, and technical parameters and ethnic issues warrant further studies.

Keywords： human immunodeficiency virus type 1     molecular cluster     transmission cluster     risk network     targeted intervention    

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Personalized medicine of type 2 diabetes

Weiping Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 1-3 doi: 10.1007/s11684-013-0241-y

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Metabolomics in human type 2 diabetes research

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 4-13 doi: 10.1007/s11684-013-0248-4

Abstract: current findings of metabolomic studies in human investigations with the most common form of diabetes, type

Keywords： metabolomics     type 2 diabetes     metabolic pathway     mass spectrometry     nuclear magnetic resonance (NMR)    

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Correction to: Effect of wood dust type on mechanical properties, wear behavior, biodegradability, and

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 4,   Pages 1071-1071 doi: 10.1007/s11709-021-0736-6

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Stability analysis of uncertain fractional-order neutral-type delay systems with actuator saturation Research Articles

Zahra Sadat Aghayan, Alireza Alfi, J. A. Tenreiro Machado,a_alfi@shahroodut.ac.ir

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 10,   Pages 1402-1412 doi: 10.1631/FITEE.2000438

Abstract: This study analyzes the problem of of fractional-order delay systems of neutral type under actuator

Keywords： 分数阶系统；稳定性；中立时滞；鲁棒性；饱和性    

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The mechanisms linking adiposopathy to type 2 diabetes

Jichun Yang, Jihong Kang, Youfei Guan

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 433-444 doi: 10.1007/s11684-013-0288-9

Abstract: pancreatic β cell dysfunction and liver insulin resistance, which are the decisive factors causing typeregarding the effects of adiposopathy-related lipotoxicity and cytokine toxicity on the development of type

Keywords： obesity     adiposopathy     lipotoxicity     adipokines     diabetes    

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Mechanical performance analysis and stiffness test of a new type of suspension bridge

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1160-1180 doi: 10.1007/s11709-021-0760-6

Abstract: A new type of suspension bridge is proposed based on the gravity stiffness principle.A new type of railway suspension bridge with a span of 340 m and a highway suspension bridge with a spanA stiffness test was carried out on the new type of suspension bridge with a small span, and the results

Keywords： new type of suspension bridge     stiffness test     mechanical performance     railway bridge     space truss    

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Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 427-437 doi: 10.1007/s11684-018-0672-6

Abstract: Desmoid-type fibromatosis (DF) is a rare monoclonal fibroblastic proliferation that is characterized

Keywords： targeted therapy     desmoid-type fibromatosis     tyrosine kinase inhibitor     γ-secretase inhibitor    

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Development of an axial-type fan with an optimization method

Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,

Frontiers in Energy 2009, Volume 3, Issue 4,   Pages 414-422 doi: 10.1007/s11708-009-0038-5

Abstract: An axial-type fan that operates at a relative total pressure of 671Pa and a static pressure ofPrior to the optimization of the fan blade, a three-dimensional axial-type fan blade is designed basedtests show that this optimization method can improve the efficiency and operating pressures on axial-type

Keywords： axial-type fan     gradient method     free-vortex method     design variable     total pressure     static pressure     operating    

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Low-temperature CO oxidation over Au-doped 13X-type zeolite catalysts: preparation and catalytic activity

Qing YE, Donghui LI, Jun ZHAO, Jiansheng ZHAO, Tianfang KANG, Shuiyuan CHENG

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 4,   Pages 497-504 doi: 10.1007/s11783-011-0256-z

Abstract: Au-supported 13X-type zeolite (Au/13X) was synthesized using a common deposition–precipitation (DP) method

Keywords： 13X-type zeolite     CO oxidation     gold solution     pH     calcination temperature    

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Title Author Date Type Operation

Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Journal Article

Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia

Journal Article

Properties of La1-xCexCoO3 system perovskite-type catalysts for diesel engine exhaust removal

GONG Cairong, FAN Guoliang, HOU Yanfeng, ZHANG Zhongrong, SONG Chonglin, HUANG Qifei

Journal Article

Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Journal Article

New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

Journal Article

Molecular network-based intervention brings us closer to ending the HIV pandemic

Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang

Journal Article

Personalized medicine of type 2 diabetes

Weiping Jia

Journal Article

Metabolomics in human type 2 diabetes research

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Journal Article

Correction to: Effect of wood dust type on mechanical properties, wear behavior, biodegradability, and

Journal Article

Stability analysis of uncertain fractional-order neutral-type delay systems with actuator saturation

Zahra Sadat Aghayan, Alireza Alfi, J. A. Tenreiro Machado,a_alfi@shahroodut.ac.ir

Journal Article

The mechanisms linking adiposopathy to type 2 diabetes

Jichun Yang, Jihong Kang, Youfei Guan

Journal Article

Mechanical performance analysis and stiffness test of a new type of suspension bridge

Journal Article

Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Journal Article

Development of an axial-type fan with an optimization method

Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,

Journal Article

Low-temperature CO oxidation over Au-doped 13X-type zeolite catalysts: preparation and catalytic activity

Qing YE, Donghui LI, Jun ZHAO, Jiansheng ZHAO, Tianfang KANG, Shuiyuan CHENG

Journal Article